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TRUPCR® AML Panel Kit

The TRUPCR® AML Panel Kit is intended for the qualitative detection of diagnostic and prognostic markers of acute myelogenous leukaemia (AML) in peripheral blood samples on conventional and Real-time PCR technologies. Acute myeloid leukaemia (AML) is a group of haematological diseases, phenotypic and genetically heterogeneous, characterized by clonal expansion of myeloid precursors with diminished capacity for differentiation. AML represents 15 to 20% of acute leukaemia cases in children and 80% in adults. Myelogenous leukaemia is present when myeloid cell lineages such as granulocytes or monocytes are affected.

TRUPCR® AML panel Kit is a combination of conventional PCR and Real-time PCR. TRUPCR® AML Panel kit is a comprehensive kit which includes complete cDNA chemistry for RNA based transcripts.

Key Features:

  • TRUPCR® AML Panel Kit allows comprehensive detection of most common diagnostic and prognostic markers for acute myelogenous leukaemia (AML).
  • It detects most common variants of transcripts in the fusion gene and most common mutations in prognostics markers.
  • The kit offers sensitivity to detect up to 10 copies of fusion transcripts for AML1-ETO, CBFB- MYH11, BCR-ABL1, PML-RARA and up to 1% mutant allele in background of 98% wild type allele for c-KIT, NPM1, FLT3-ITD and FLT3-D835.
  • All the reagents for cDNA chemistry, PCR and Real-time PCR are included in the kit.
  • It is compatible with various Real-time & Conventional PCR instruments.
  • Easy-to-use, rapid, reliable, comprehensive and cost-effective tests.

AML results from clonal transformation of hematopoietic precursors through the acquisition of chromosomal rearrangements and multiple gene mutations that confer a proliferative and survival advantage and impair hematopoietic differentiation. These key oncogenic events are often classified according to the two hits model proposed by Gilliland in 2001. This model hypothesizes that AML is the consequence of a collaboration between at least two broad classes of mutations, Class I mutations that confer proliferative and survival advantages (FLT3, KIT, RAS, JAK2, CBL, PNPN11), and Class II mutations that affect the processes of cell differentiation and apoptosis (PML-RARA, RUNX1-RUNX1T1, CBFB-MYH11, CEBPA, NPM1). However, recent studies using massively parallel sequencing technologies have identified other group of mutations that do not conform to any of the two classes; therefore, they have not been classified (DNMT3a, TET2, IDH1, IDH2, WT1); however, these mainly promote epigenetic modifications. Recent evidence shows that the identification of new AML biomarkers contributes to a better understanding of the molecular basis of the disease, are significantly useful in screening, diagnosis, prognosis and monitoring of AML, as well as the possibility of predicting each individual´s response to treatment.

Mutation Variants detected by TRUPCR® AML Panel Kit

No. GENE VARIENT
1 BCR-ABL1 e13a2 & e14a2 (p210)
e1a2 (p190)
2 PML-RARA BCR1
BCR2
BCR3
3 AML1-ETO RUNX1-RUNX1T1
4 CBFB-MYH11 Type A
Type E
Type D
5 FLT3 ITD
D835
6 NPM1 Type A
Type B
7 C-KIT D816V
8 ABL1 Control gene

Ordering Information:

CAT. NO. PRODUCT CONTENTS
3B1401 TRUPCR® AML Panel Kit 24 Reactions
3B1402 TRUPCR® AML Panel Kit 48 Reactions
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With an experienced team and innovative products, TRUPCR Europe supplies high quality qPCR molecular diagnostic products throughout Europe.

We offer technical support and training on all our products and are committed to increasing the efficiency of laboratory testing and enhancing patient care.

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  • Home
  • Products
    • Oncology & Haematology
      • Individual Markers
        • C-KIT Mutation Detection Kit
        • CALR Kit
        • FLT3 Mutation Detection Kit
        • NPM1 Qualitative KIT
        • NPM1 Mutation Quantitative Kit
        • JAK2 KIT
        • JAK-2 Allele Burden Kit
        • PML-RARA Quantitative
        • PML-RARA Qualitative (BCR1, BCR2, BCR3)
      • Individual Markers BCR-ABL1
        • BCR-ABL1 b2a2/b3a2 Differentiation Kit
        • BCR-ABL Quantitative Kit
        • BCR ABL Qualitative Kit
        • BCR-ABL1 Transcript Screening Kit
      • Solid Tumours Individual Markers
        • EGFR Real-time PCR Kit
        • KRAS Real-time PCR Kit
        • MGMT Methylation Detection Kit
        • BRAF Mutation Kit
        • NRAS Mutation Kit
        • ROS1 Fusions Detection Kit
      • Panel Kits
        • ALL PCR Panel Kit
        • AML Panel Kit
        • MPN Panel Kit
        • Paediatric Leukemia Panel Kit
    • Extraction
      • Silica extraction
        • Blood DNA Extraction Kit
        • Blood RNA Extraction Kit
        • Total Viral Nucleic Acid Extraction Kit
        • Viral RNA Extraction Kit
        • MTB DNA Extraction Kit
        • Total Viral Nucleic Acid Extraction Kit
        • Tissue DNA Extraction Kit
    • Infectious Disease
      • Panel Kits
        • Influenza Panel Kit
        • Flu Panel with RSV detection Kit
        • NAAT Kit
        • Neuro Panel Kit
        • STD Panel Kit
        • Respiratory Pathogen Panel Kit
        • TORCH Panel Kit
        • Tropical Fever Panel Kit
        • UTI ID Panel Kit
      • Individual Markers: STI
        • CMV QT Kit
        • CT/NG Real-Time PCR Detection Kit
        • EBV Virus Detection Kit
        • HBV Viral Load PCR Kit
        • HCV Viral Load Kit
        • HIV Viral Load Kit
        • HCV Genotyping Kit
        • HIV 1/2 Detection Kit
        • HSV Real-time PCR Detection Kit
        • HPV High Risk (E6/E7) Kit
        • HPV 16 & 18 Kit
      • Bacterial Diseases
        • MTB Kit (Nested single step real-time PCR)
        • One Step nested Kit (MTBC and NTM)
        • Leptospira Detection Kit
      • Parasitic Diseases
        • Toxoplasma Detection Kit
      • Viral Diseases
        • BKV Viral Load Kit
        • SARS-CoV-2 RT-qPCR Kit
        • H1N1 (Swine Flu) Detection PCR Kit
      • Vector Borne Diseases
        • Zika Virus Detection Kit
        • Chikungunya Detection Kit
        • Dengue Detection kit
        • Dengue / Chikungunya PCR Kit
        • Malaria Detection Kit
    • Human Genetics
      • Human Genetics
        • Factor II Prothrombin Mutation (G20210A) Detection Kit
        • Factor V Leiden Mutation (G1691A) Detection Kit
        • MTHFR Mutation Kit
        • Coagulation/ Thrombophilia Panel qPCR Kit
        • HLA B27 PCR Kit
    • Antimicrobial Resistance
      • Panel Kits
        • UTI AST Panel Kit
      • Individual Markers
        • MRSA Detection Kit
        • Rif/INH MTB Drug Resistant Detection Kit
        • Rifampicin Resistant MTB Kit
  • Careers
  • Events
  • News
  • About us
  • Contact
TRUPCR Europe