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TRUPCR® C-KIT Mutation Detection Kit

The TRUPCR® C-KIT Mutation Detection is a PCR-based in vitro diagnostic test designed to detect D816V in the C-KIT gene in genomic DNA extracted from peripheral blood of patients diagnosed with acute myelogenous leukaemia (AML) or other malignancy.

KIT is a receptor tyrosine kinase involved in proliferation, differentiation, and survival. KIT mutations affect predominantly exons 8 or 17, lead to a gain of function, and occur in 2%–14% of all cases of AML. The incidence of KIT mutations is higher in core-binding factor leukaemia, being found in about 7%–46% of cases. The presence of KIT mutations in core binding factor leukaemia is generally accepted to be associated with a worse prognosis. The D816V mutation results in an amino acid substitution at position 816 in KIT, from an aspartic acid (D) to a valine (V). This mutation is associated with intermediate prognosis in AML in patients with t(8;21), inv(16), or t(16;16) karyotype. In patients without KIT mutations, t(8;21), inv(16), and t(16;16) are associated with favourable prognosis.

Key Features:

  • TRUPCR® C-KIT mutation detection Kit allows sensitive and specific detection of most common D816V in a single run.
  • The kit offers sensitivity to detect up to 1% mutant allele in background of 99% wild type alleles.
  • It is compatible with various Real-time PCR instruments
  • Easy-to-use, rapid, reliable, comprehensive and cost-effective tests.

Ordering Information:

CAT. NO. PRODUCT CONTENTS
3B1341 TRUPCR® C-KIT Mutation Detection Kit 24 Reactions
3B1342 TRUPCR® C-KIT Mutation Detection Kit 48 Reactions
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  • Home
  • Products
    • Oncology & Haematology
      • Individual Markers
        • C-KIT Mutation Detection Kit
        • CALR Kit
        • FLT3 Mutation Detection Kit
        • NPM1 Qualitative KIT
        • NPM1 Mutation Quantitative Kit
        • JAK2 KIT
        • JAK-2 Allele Burden Kit
        • PML-RARA Quantitative
        • PML-RARA Qualitative (BCR1, BCR2, BCR3)
      • Individual Markers BCR-ABL1
        • BCR-ABL1 b2a2/b3a2 Differentiation Kit
        • BCR-ABL Quantitative Kit
        • BCR ABL Qualitative Kit
        • BCR-ABL1 Transcript Screening Kit
      • Solid Tumours Individual Markers
        • EGFR Real-time PCR Kit
        • KRAS Real-time PCR Kit
        • MGMT Methylation Detection Kit
        • BRAF Mutation Kit
        • NRAS Mutation Kit
        • ROS1 Fusions Detection Kit
      • Panel Kits
        • ALL PCR Panel Kit
        • AML Panel Kit
        • MPN Panel Kit
        • Paediatric Leukemia Panel Kit
    • Extraction
      • Silica extraction
        • Blood DNA Extraction Kit
        • Blood RNA Extraction Kit
        • Total Viral Nucleic Acid Extraction Kit
        • Viral RNA Extraction Kit
        • MTB DNA Extraction Kit
        • Total Viral Nucleic Acid Extraction Kit
        • Tissue DNA Extraction Kit
    • Infectious Disease
      • Panel Kits
        • Influenza Panel Kit
        • Flu Panel with RSV detection Kit
        • NAAT Kit
        • Neuro Panel Kit
        • STD Panel Kit
        • Respiratory Pathogen Panel Kit
        • TORCH Panel Kit
        • Tropical Fever Panel Kit
        • UTI ID Panel Kit
      • Individual Markers: STI
        • CMV QT Kit
        • CT/NG Real-Time PCR Detection Kit
        • EBV Virus Detection Kit
        • HBV Viral Load PCR Kit
        • HCV Viral Load Kit
        • HIV Viral Load Kit
        • HCV Genotyping Kit
        • HIV 1/2 Detection Kit
        • HSV Real-time PCR Detection Kit
        • HPV High Risk (E6/E7) Kit
        • HPV 16 & 18 Kit
      • Bacterial Diseases
        • MTB Kit (Nested single step real-time PCR)
        • One Step nested Kit (MTBC and NTM)
        • Leptospira Detection Kit
      • Parasitic Diseases
        • Toxoplasma Detection Kit
      • Viral Diseases
        • BKV Viral Load Kit
        • SARS-CoV-2 RT-qPCR Kit
        • H1N1 (Swine Flu) Detection PCR Kit
      • Vector Borne Diseases
        • Zika Virus Detection Kit
        • Chikungunya Detection Kit
        • Dengue Detection kit
        • Dengue / Chikungunya PCR Kit
        • Malaria Detection Kit
    • Human Genetics
      • Human Genetics
        • Factor II Prothrombin Mutation (G20210A) Detection Kit
        • Factor V Leiden Mutation (G1691A) Detection Kit
        • MTHFR Mutation Kit
        • Coagulation/ Thrombophilia Panel qPCR Kit
        • HLA B27 PCR Kit
    • Antimicrobial Resistance
      • Panel Kits
        • UTI AST Panel Kit
      • Individual Markers
        • MRSA Detection Kit
        • Rif/INH MTB Drug Resistant Detection Kit
        • Rifampicin Resistant MTB Kit
  • Careers
  • Events
  • News
  • About us
  • Contact
TRUPCR Europe