Call us: +44 (0) 161 943 4731
info@trupcr.com
TRUPCR EuropeTRUPCR EuropeTRUPCR EuropeTRUPCR Europe
  • Home
  • Products
      • Oncology & Haematology
        • Individual Markers
          • C-KIT Mutation Detection Kit
          • CALR Kit
          • FLT3 Mutation Detection Kit
          • NPM1 Qualitative KIT
          • NPM1 Mutation Quantitative Kit
          • JAK2 KIT
          • JAK-2 Allele Burden Kit
          • PML-RARA Quantitative
          • PML-RARA Qualitative (BCR1, BCR2, BCR3)
        • Individual Markers BCR-ABL1
          • BCR-ABL1 b2a2/b3a2 Differentiation Kit
          • BCR-ABL Quantitative Kit
          • BCR ABL Qualitative Kit
          • BCR-ABL1 Transcript Screening Kit
        • Solid Tumours Individual Markers
          • EGFR Real-time PCR Kit
          • KRAS Real-time PCR Kit
          • MGMT Methylation Detection Kit
          • BRAF Mutation Kit
          • NRAS Mutation Kit
          • ROS1 Fusions Detection Kit
        • Panel Kits
          • ALL PCR Panel Kit
          • AML Panel Kit
          • MPN Panel Kit
          • Paediatric Leukemia Panel Kit
      • Extraction
        • Silica extraction
          • Blood DNA Extraction Kit
          • Blood RNA Extraction Kit
          • Total Viral Nucleic Acid Extraction Kit
          • Viral RNA Extraction Kit
          • MTB DNA Extraction Kit
          • Total Viral Nucleic Acid Extraction Kit
          • Tissue DNA Extraction Kit
      • Infectious Disease
        • Panel Kits
          • Influenza Panel Kit
          • Flu Panel with RSV detection Kit
          • NAAT Kit
          • Neuro Panel Kit
          • STD Panel Kit
          • Respiratory Pathogen Panel Kit
          • TORCH Panel Kit
          • Tropical Fever Panel Kit
          • UTI ID Panel Kit
        • Individual Markers: STI
          • CMV QT Kit
          • CT/NG Real-Time PCR Detection Kit
          • EBV Virus Detection Kit
          • HBV Viral Load PCR Kit
          • HCV Viral Load Kit
          • HIV Viral Load Kit
          • HCV Genotyping Kit
          • HIV 1/2 Detection Kit
          • HSV Real-time PCR Detection Kit
          • HPV High Risk (E6/E7) Kit
          • HPV 16 & 18 Kit
        • Bacterial Diseases
          • MTB Kit (Nested single step real-time PCR)
          • One Step nested Kit (MTBC and NTM)
          • Leptospira Detection Kit
        • Parasitic Diseases
          • Toxoplasma Detection Kit
        • Viral Diseases
          • BKV Viral Load Kit
          • SARS-CoV-2 RT-qPCR Kit
          • H1N1 (Swine Flu) Detection PCR Kit
        • Vector Borne Diseases
          • Zika Virus Detection Kit
          • Chikungunya Detection Kit
          • Dengue Detection kit
          • Dengue / Chikungunya PCR Kit
          • Malaria Detection Kit
      • Human Genetics
        • Human Genetics
          • Factor II Prothrombin Mutation (G20210A) Detection Kit
          • Factor V Leiden Mutation (G1691A) Detection Kit
          • MTHFR Mutation Kit
          • Coagulation/ Thrombophilia Panel qPCR Kit
          • HLA B27 PCR Kit
      • Antimicrobial Resistance
        • Panel Kits
          • UTI AST Panel Kit
        • Individual Markers
          • MRSA Detection Kit
          • Rif/INH MTB Drug Resistant Detection Kit
          • Rifampicin Resistant MTB Kit
  • Careers
  • Events
  • News
  • About us
  • Contact

TRUPCR® CALR Kit

The TRUPCR® CALR Kit is qualitative assay for the detection of CALR mutations in genomic DNA from whole blood of subjects suspected of myeloproliferative neoplasms (MPN). The TRUPCR® CALR Kit enables the identification of the two major CALR mutations (Type 1 and Type 2).

MPN are a group of diseases that affect blood-cell formation. In all forms of MPN, a bone marrow problem leads to increased levels of blood cells circulating in the bloodstream. MPN is characterized by chronic accumulation of different mature blood cell types in blood, which are either Philadelphia chromosome positive (Ph+) or negative (Ph–). Calreticulin (CALR) is a highly conserved endoplasmic reticulum (ER) luminal Ca2+-binding chaperone protein with a critical role in the process of glycoprotein folding and a number of other cellular functions. Calreticulin is encoded by the CALR gene on the chromosome 19. Somatic mutations in exon 9 of CALR are the second most prevalent acquired nucleotide changes in Ph-negative myeloproliferative neoplasms (MPNs), except of polycythaemia vera (PV). The two specific mutations are most common, L367fs*46 (Type 1 mutation) which represents a 52-bp deletion flanked by 7 base pairs of identical sequence and a K385fs*47(Type 2), which results from a 5-bp insertion, and representing an inverse duplication of the five nucleotides preceding the insertion.

Key Features:

  • TRUPCR® CALR Kit allows sensitive and specific detection of most common CALR Mutations in a single run.
  • The kit offers sensitivity to detect up to 1% mutant allele in background of 99% wild type alleles.
  • It is compatible with various Real-time PCR instruments.
  • Easy-to-use, rapid, reliable, comprehensive and cost-effective tests.

Ordering Information:

CAT. NO. PRODUCT CONTENTS
3B1351 TRUPCR® CALR Kit 24 Reactions
3B1352 TRUPCR® CALR Kit 48 Reactions
Back to products list

To arrange a visit or to enquire about any of our products, please feel free to contact us and one of our representatives will be in touch within 24 hours

CONTACT US

About us

With an experienced team and innovative products, TRUPCR Europe supplies high quality qPCR molecular diagnostic products throughout Europe.

We offer technical support and training on all our products and are committed to increasing the efficiency of laboratory testing and enhancing patient care.

Terms & Conditions
Privacy Policy

Quick Links

  • Home Page
  • Latest News
  • Antimicrobial Resistance
  • Extraction
  • Human Genetics
  • Infectious Disease
  • Oncology & Haematology
  • Contact us

Our Location

Unit 6, Williams House, Lloyd Street
North, Manchester Science Park,
Manchester M15 6SE

Contact Us

General enquires: info@trupcr.com
Technical support: techsupport@trupcr.com
Sales: sales@trupcr.com
Orders: orders@trupcr.com

Tel: +44 (0) 161 943 4731

 

Copyright © 2023 TRUPCR Europe Ltd - All Rights Reserved. Registered in England & Wales no. 12060630
  • Home
  • Products
    • Oncology & Haematology
      • Individual Markers
        • C-KIT Mutation Detection Kit
        • CALR Kit
        • FLT3 Mutation Detection Kit
        • NPM1 Qualitative KIT
        • NPM1 Mutation Quantitative Kit
        • JAK2 KIT
        • JAK-2 Allele Burden Kit
        • PML-RARA Quantitative
        • PML-RARA Qualitative (BCR1, BCR2, BCR3)
      • Individual Markers BCR-ABL1
        • BCR-ABL1 b2a2/b3a2 Differentiation Kit
        • BCR-ABL Quantitative Kit
        • BCR ABL Qualitative Kit
        • BCR-ABL1 Transcript Screening Kit
      • Solid Tumours Individual Markers
        • EGFR Real-time PCR Kit
        • KRAS Real-time PCR Kit
        • MGMT Methylation Detection Kit
        • BRAF Mutation Kit
        • NRAS Mutation Kit
        • ROS1 Fusions Detection Kit
      • Panel Kits
        • ALL PCR Panel Kit
        • AML Panel Kit
        • MPN Panel Kit
        • Paediatric Leukemia Panel Kit
    • Extraction
      • Silica extraction
        • Blood DNA Extraction Kit
        • Blood RNA Extraction Kit
        • Total Viral Nucleic Acid Extraction Kit
        • Viral RNA Extraction Kit
        • MTB DNA Extraction Kit
        • Total Viral Nucleic Acid Extraction Kit
        • Tissue DNA Extraction Kit
    • Infectious Disease
      • Panel Kits
        • Influenza Panel Kit
        • Flu Panel with RSV detection Kit
        • NAAT Kit
        • Neuro Panel Kit
        • STD Panel Kit
        • Respiratory Pathogen Panel Kit
        • TORCH Panel Kit
        • Tropical Fever Panel Kit
        • UTI ID Panel Kit
      • Individual Markers: STI
        • CMV QT Kit
        • CT/NG Real-Time PCR Detection Kit
        • EBV Virus Detection Kit
        • HBV Viral Load PCR Kit
        • HCV Viral Load Kit
        • HIV Viral Load Kit
        • HCV Genotyping Kit
        • HIV 1/2 Detection Kit
        • HSV Real-time PCR Detection Kit
        • HPV High Risk (E6/E7) Kit
        • HPV 16 & 18 Kit
      • Bacterial Diseases
        • MTB Kit (Nested single step real-time PCR)
        • One Step nested Kit (MTBC and NTM)
        • Leptospira Detection Kit
      • Parasitic Diseases
        • Toxoplasma Detection Kit
      • Viral Diseases
        • BKV Viral Load Kit
        • SARS-CoV-2 RT-qPCR Kit
        • H1N1 (Swine Flu) Detection PCR Kit
      • Vector Borne Diseases
        • Zika Virus Detection Kit
        • Chikungunya Detection Kit
        • Dengue Detection kit
        • Dengue / Chikungunya PCR Kit
        • Malaria Detection Kit
    • Human Genetics
      • Human Genetics
        • Factor II Prothrombin Mutation (G20210A) Detection Kit
        • Factor V Leiden Mutation (G1691A) Detection Kit
        • MTHFR Mutation Kit
        • Coagulation/ Thrombophilia Panel qPCR Kit
        • HLA B27 PCR Kit
    • Antimicrobial Resistance
      • Panel Kits
        • UTI AST Panel Kit
      • Individual Markers
        • MRSA Detection Kit
        • Rif/INH MTB Drug Resistant Detection Kit
        • Rifampicin Resistant MTB Kit
  • Careers
  • Events
  • News
  • About us
  • Contact
TRUPCR Europe