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TRUPCR® FLT3 Mutation Detection Kit

The TRUPCR® FLT3 Mutation Detection is a PCR-based in vitro diagnostic test designed to detect internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutation (D835-I836) in the FLT3 gene in genomic DNA extracted from mononuclear cells obtained from peripheral blood of patients diagnosed with acute myelogenous leukaemia (AML). TRUPCR® FLT3 Mutation Detection Kit is a combination of conventional PCR and Real time PCR.

The FLT3 gene encodes a receptor tyrosine kinase (RTK) that plays a critical role in haematopoiesis and cell growth because it regulates diverse cellular processes such as proliferation, differentiation and apoptosis. The most common mutation in FLT3 involves internal tandem duplication (ITD) between exons 14 and 15 in the juxtamembrane domain, which varies in length and position of patient to patient. The main impact of FLT3-ITD is its association with high blast accounts, increased risk of relapse and decreased survival. The second common type of mutation in FLT3 is missense mutations in exon 20 of the activation loop (A-loop) in the tyrosine kinase domain (TKD). Almost all these mutations involve the substitution of an aspartate with a tyrosine at codon 835 (D835Y) by a point mutation (GAT→TAT). These mutations produce a conformational change in the protein, disrupting the energy balance required to stabilize the closed form, eliminating its autoinhibitory function that causes its constitutive activation.

Key Features:

  • TRUPCR® FLT3 mutation detection Kit allows sensitive and specific detection of most common FLT3-ITD and D835-I836 in a single run.
  • The kit offers sensitivity to detect up to 1% mutant allele in background of 99% wild type alleles and minimum ITD of 20bp.
  • It is compatible with various Real-time & conventional PCR instruments.
  • Easy-to-use, rapid, reliable, comprehensive and cost-effective tests.

Ordering Information:

CAT. NO. PRODUCT CONTENTS
3B1313 TRUPCR® FLT3 Mutation Detection Kit 24 Reactions
3B1314 TRUPCR® FLT3 Mutation Detection Kit 48 Reactions
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  • Home
  • Products
    • Oncology & Haematology
      • Individual Markers
        • C-KIT Mutation Detection Kit
        • CALR Kit
        • FLT3 Mutation Detection Kit
        • NPM1 Qualitative KIT
        • NPM1 Mutation Quantitative Kit
        • JAK2 KIT
        • JAK-2 Allele Burden Kit
        • PML-RARA Quantitative
        • PML-RARA Qualitative (BCR1, BCR2, BCR3)
      • Individual Markers BCR-ABL1
        • BCR-ABL1 b2a2/b3a2 Differentiation Kit
        • BCR-ABL Quantitative Kit
        • BCR ABL Qualitative Kit
        • BCR-ABL1 Transcript Screening Kit
      • Solid Tumours Individual Markers
        • EGFR Real-time PCR Kit
        • KRAS Real-time PCR Kit
        • MGMT Methylation Detection Kit
        • BRAF Mutation Kit
        • NRAS Mutation Kit
        • ROS1 Fusions Detection Kit
      • Panel Kits
        • ALL PCR Panel Kit
        • AML Panel Kit
        • MPN Panel Kit
        • Paediatric Leukemia Panel Kit
    • Extraction
      • Silica extraction
        • Blood DNA Extraction Kit
        • Blood RNA Extraction Kit
        • Total Viral Nucleic Acid Extraction Kit
        • Viral RNA Extraction Kit
        • MTB DNA Extraction Kit
        • Total Viral Nucleic Acid Extraction Kit
        • Tissue DNA Extraction Kit
    • Infectious Disease
      • Panel Kits
        • Influenza Panel Kit
        • Flu Panel with RSV detection Kit
        • NAAT Kit
        • Neuro Panel Kit
        • STD Panel Kit
        • Respiratory Pathogen Panel Kit
        • TORCH Panel Kit
        • Tropical Fever Panel Kit
        • UTI ID Panel Kit
      • Individual Markers: STI
        • CMV QT Kit
        • CT/NG Real-Time PCR Detection Kit
        • EBV Virus Detection Kit
        • HBV Viral Load PCR Kit
        • HCV Viral Load Kit
        • HIV Viral Load Kit
        • HCV Genotyping Kit
        • HIV 1/2 Detection Kit
        • HSV Real-time PCR Detection Kit
        • HPV High Risk (E6/E7) Kit
        • HPV 16 & 18 Kit
      • Bacterial Diseases
        • MTB Kit (Nested single step real-time PCR)
        • One Step nested Kit (MTBC and NTM)
        • Leptospira Detection Kit
      • Parasitic Diseases
        • Toxoplasma Detection Kit
      • Viral Diseases
        • BKV Viral Load Kit
        • SARS-CoV-2 RT-qPCR Kit
        • H1N1 (Swine Flu) Detection PCR Kit
      • Vector Borne Diseases
        • Zika Virus Detection Kit
        • Chikungunya Detection Kit
        • Dengue Detection kit
        • Dengue / Chikungunya PCR Kit
        • Malaria Detection Kit
    • Human Genetics
      • Human Genetics
        • Factor II Prothrombin Mutation (G20210A) Detection Kit
        • Factor V Leiden Mutation (G1691A) Detection Kit
        • MTHFR Mutation Kit
        • Coagulation/ Thrombophilia Panel qPCR Kit
        • HLA B27 PCR Kit
    • Antimicrobial Resistance
      • Panel Kits
        • UTI AST Panel Kit
      • Individual Markers
        • MRSA Detection Kit
        • Rif/INH MTB Drug Resistant Detection Kit
        • Rifampicin Resistant MTB Kit
  • Careers
  • Events
  • News
  • About us
  • Contact
TRUPCR Europe