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TRUPCR® MPN Panel Kit

The TRUPCR® MPN Panel Kit is intended for the qualitative detection of JAK2-V617F, CALR, MPL W515K/L mutations and BCR-ABL1 translocation in Myeloproliferative neoplasms (MPNs) in peripheral blood samples using real time PCR system.

Myeloproliferative neoplasms (MPN), previously called myeloproliferative disorders (MPD) are a group of diseases that are caused by an overproduction of one or more blood cell types (red cells, white cells or platelets) in the bone marrow. Myeloproliferative neoplasms (MPNs) are associated with dysregulation of tyrosine kinases, leading to abnormal downstream signaling pathways and increased cellular proliferation. Based on the presence or absence of the Philadelphia chromosome (BCR/ABL1 translocation), MPN are broadly grouped into two categories – Philadelphia positive (chronic myeloid leukemia) and Philadelphia negative (polycythemia vera, essential thrombocythemia and myelofibrosis). The Philadelphia chromosome negative MPNs are characterized by mutations in various genes such as JAK2, MPL, CALR, PDGFRA, PDGFRB, FGFR1 and KIT. In addition, multiple chromosome abnormalities have been defined.

TRUPCR® MPN panel Kit is a Real time PCR assay which is based on fluorescent signal generated from the presence of an oligonucleotide probe specific for target DNA sequence. TRUPCR® MPN Panel kit is a comprehensive kit which includes complete cDNA chemistry for RNA based transcripts.

Key Features:

  • TRUPCR® MPN Panel Kit allows comprehensive detection of most common diagnostic and prognostic markers for Myeloproliferative neoplasms (MPN).
  • It detects most common variants of transcripts in the fusion gene and most common mutations in prognostics markers.
  • The kit offers sensitivity to detect up to 10 copies of fusion transcripts BCR-ABL1 and up to 1% mutant allele in background of 99% wild type allele for JAK 2, CALR and MPL genes.
  • All the reagents for cDNA chemistry, PCR and real-time PCR are included in the kit.
  • It is compatible with various Real Time & Conventional PCR instruments.
  • Easy-to-use, rapid, reliable, comprehensive and cost-effective tests

Mutation Variants detected by TRUPCR® MPN Panel Kit:

No. GENE VARIENT
1 BCR-ABL1 e13a2 & e14a2 (p210)
e1a2 (p190)
2 JAK 2 V617F
3 CALR Type 1 and Type 2
4 MPL W515L and W515K
5 ABL1 Control gene

Ordering Information:

CAT. NO. PRODUCT CONTENTS
3B1303 TRUPCR® MPN Panel Kit 24 Reactions
3B1304 TRUPCR® MPN Panel Kit 48 Reactions
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With an experienced team and innovative products, TRUPCR Europe supplies high quality qPCR molecular diagnostic products throughout Europe.

We offer technical support and training on all our products and are committed to increasing the efficiency of laboratory testing and enhancing patient care.

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  • Home
  • Products
    • Oncology & Haematology
      • Individual Markers
        • C-KIT Mutation Detection Kit
        • CALR Kit
        • FLT3 Mutation Detection Kit
        • NPM1 Qualitative KIT
        • NPM1 Mutation Quantitative Kit
        • JAK2 KIT
        • JAK-2 Allele Burden Kit
        • PML-RARA Quantitative
        • PML-RARA Qualitative (BCR1, BCR2, BCR3)
      • Individual Markers BCR-ABL1
        • BCR-ABL1 b2a2/b3a2 Differentiation Kit
        • BCR-ABL Quantitative Kit
        • BCR ABL Qualitative Kit
        • BCR-ABL1 Transcript Screening Kit
      • Solid Tumours Individual Markers
        • EGFR Real-time PCR Kit
        • KRAS Real-time PCR Kit
        • MGMT Methylation Detection Kit
        • BRAF Mutation Kit
        • NRAS Mutation Kit
        • ROS1 Fusions Detection Kit
      • Panel Kits
        • ALL PCR Panel Kit
        • AML Panel Kit
        • MPN Panel Kit
        • Paediatric Leukemia Panel Kit
    • Extraction
      • Silica extraction
        • Blood DNA Extraction Kit
        • Blood RNA Extraction Kit
        • Total Viral Nucleic Acid Extraction Kit
        • Viral RNA Extraction Kit
        • MTB DNA Extraction Kit
        • Total Viral Nucleic Acid Extraction Kit
        • Tissue DNA Extraction Kit
    • Infectious Disease
      • Panel Kits
        • Influenza Panel Kit
        • Flu Panel with RSV detection Kit
        • NAAT Kit
        • Neuro Panel Kit
        • STD Panel Kit
        • Respiratory Pathogen Panel Kit
        • TORCH Panel Kit
        • Tropical Fever Panel Kit
        • UTI ID Panel Kit
      • Individual Markers: STI
        • CMV QT Kit
        • CT/NG Real-Time PCR Detection Kit
        • EBV Virus Detection Kit
        • HBV Viral Load PCR Kit
        • HCV Viral Load Kit
        • HIV Viral Load Kit
        • HCV Genotyping Kit
        • HIV 1/2 Detection Kit
        • HSV Real-time PCR Detection Kit
        • HPV High Risk (E6/E7) Kit
        • HPV 16 & 18 Kit
      • Bacterial Diseases
        • MTB Kit (Nested single step real-time PCR)
        • One Step nested Kit (MTBC and NTM)
        • Leptospira Detection Kit
      • Parasitic Diseases
        • Toxoplasma Detection Kit
      • Viral Diseases
        • BKV Viral Load Kit
        • SARS-CoV-2 RT-qPCR Kit
        • H1N1 (Swine Flu) Detection PCR Kit
      • Vector Borne Diseases
        • Zika Virus Detection Kit
        • Chikungunya Detection Kit
        • Dengue Detection kit
        • Dengue / Chikungunya PCR Kit
        • Malaria Detection Kit
    • Human Genetics
      • Human Genetics
        • Factor II Prothrombin Mutation (G20210A) Detection Kit
        • Factor V Leiden Mutation (G1691A) Detection Kit
        • MTHFR Mutation Kit
        • Coagulation/ Thrombophilia Panel qPCR Kit
        • HLA B27 PCR Kit
    • Antimicrobial Resistance
      • Panel Kits
        • UTI AST Panel Kit
      • Individual Markers
        • MRSA Detection Kit
        • Rif/INH MTB Drug Resistant Detection Kit
        • Rifampicin Resistant MTB Kit
  • Careers
  • Events
  • News
  • About us
  • Contact
TRUPCR Europe