The Nucleophosmin (NPM1) gene is one of the most commonly mutated genes in acute myeloid leukemia (AML), occurring in about 35% of AML patients at diagnosis and in approximately 60% of adult cytogenetically normal AML (CN-AML).
TRUPCR® NPM1 Qualitative Kit is an in-vitro nucleic acid amplification assay for the qualitative detection of mutation in NPM1 gene in peripheral blood samples.The detection is achieved using fluorescent probes.
TRUPCR® NPM1 Qualitative Kit is a two tube assay composed of primer probe mixture for the detection of the NPM1 mutation and a reference control gene.
Three types of NPM1 mutation variants detected by this kit are given below:
- NPM1 mutation A (c.860_863dupTCTG)
- NPM1 mutation B (c.863_864insCATG)
- NPM1 mutation D (c.863_864insCCTG)
